Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Proteochem Inc Formic Acid Ampules 10X1Ml (10/Pk)
Proteomics Grade Formic Acid Ampules 10 x 1.0 mL (CAS 64-18-6) recommended as an HPLC and LCMS mobile phase additive. Each Formic Acid ampule contains 1.0 mL of Proteomics Grade Formic Acid.
Sigma Aldrich Fine Chemicals Biosciences Formic acid, 64-18-6, MFCD00003297, 1 L
Linear Formula: HCOOH, Molecular Weight: 46.03, reagent grade, ≥95%.
Newcomer Supply Decalcifying Solution, Formic Acid 5%, Aqueous, 1 gallon
Newcomer Supply Decalcifying Solution, Formic Acid, 5% Aqueous, provides a moderate rate of decalcification while maintaining excellent cellular morphology. This solution is a general purpose decalcifier and is suitable for all bone specimen types from sternal or iliac crest bone marrow biopsies (light bone) to femoral head and long bone sections (compact bone). Shelf Life is 1 year from date of manufacture. Store at 15-30°C.
Medchemexpress LLC SJ1008030 formic | 97.7% | 919.96 | 1 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2. This compound inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and is suitable for leukemia research.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM
- Can be used for leukemia research
- Purity of 97.7%
- Supplied as a light yellow to yellow solid
- Molecular formula C43H45N13O9S
Medchemexpress LLC PKCiota-IN-2 formic | 99.04% | 402.36 | 50 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι), with an IC50 of 2.8 nM. It also demonstrates inhibitory activity against PKC-α and PKC-ε, exhibiting IC50s of 71 nM and 350 nM, respectively. This product is intended for research use only and is not for sale to patients.
- Potent inhibition of PKCiota.
- Exhibits inhibitory effects on PKC-alpha and PKC-epsilon.
- Available in various quantities, including solid and solution forms.
Sigma Aldrich Fine Chemicals Biosciences Formic acid >=95%, FCC, FG | 64-18-6 | MFCD00003297 | 10KG
Formic acid >=95%, FCC, FG | Purity: >=95% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 10KG
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3982132 FORMIC ACID 98-100 FOR HPLC L
Medchemexpress LLC SLB1122168 formic | C23H37N3O3 | 100 MG
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. It is intended for research use only and not for patient administration.
- Potent Spns2-mediated S1P release inhibitor
- Inhibitor with an IC50 of 94 nM
- Intended for research use
Medchemexpress LLC PKCiota-IN-2 formic | 2230055-52-2 | 99.0% | 402.36 | 25 MG
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. It also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively. This product is for research use only.
- Appearance: Solid
- Color: Light yellow to yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture and light).
- Solubility (in vitro): DMSO: 100 mg/mL (248.53 mM; requires ultrasonic).
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 50 MG
CCT367766 formic is a potent third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. This PROTAC effectively depletes pirin protein expression at low concentrations. It demonstrates a moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM. Furthermore, it shows good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. This product serves as a valuable chemical tool for researching a protein that is currently not well understood.
- Potent third-generation PROTAC.
- Targets pirin protein degradation.
- Moderate affinity for the CRBN-DDB1 complex (IC50 = 490 nM).
- Good affinity for recombinant pirin (Kd = 55 nM) and CRBN (Kd = 120 nM).
- Useful chemical tool for pirin protein studies.
Medchemexpress LLC BMT-124110 (formic) | 00-00-0 | MFCD34469994 | >98.0% | 369.46 g/mol | C21H27N3O3 | 5 MG
Small-molecule AAK1 inhibitor for laboratory research. It is a potent, selective AAK1 inhibitor (IC50 = 0.9 nM) with reported antinociceptive activity; it also inhibits BIKE (IC50 = 17 nM) and GAK (IC50 = 99 nM). Molecular formula C21H27N3O3; molecular weight 369.46 g/mol. Store powder at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month. Purity reported >98% (HPLC).
- Potent AAK1 inhibition (IC50 = 0.9 nM).
- Activity against BIKE and GAK (IC50s 17 nM and 99 nM).
- Suitable for biochemical and cellular kinase assays.
- Stable when stored as powder at -20°C.
- Supplied in milligram research quantities.
Medchemexpress LLC SLB1122168 formic | C23H37N3O3 | 10 MM * 1 ML
SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. It is intended for research use only and available in various forms, including solid and as a 10 mM * 1 mL solution in DMSO.
- Potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM
- Intended for research use only
- Purity of 99.91%
- Molecular weight of 403.56
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 100 mg/mL (247.79 mM)
- Induces a dose-dependent decrease in circulating lymphocytes in vivo
- Achieves a maximum concentration of 4 μM in rats at 2 hours post-dose with a half-life of 8 hours
- Related to respiratory, inflammatory, and pulmonary diseases, and lung fibrosis
- Affects inflammation/immunology, GPCR/G protein, and LPL receptor signaling pathways